Dr Maryse Lapeyre-Mestre is MD, PhD, qualified in Clinical Pharmacology, Public Health and Pharmacoepidemiology. Among her hospital and public health activities, she is the Director of the Centre d’Evaluation et d’Information sur la Pharmacodépendance – Addictovigilance (CEIP-A) of Toulouse since 2003. In parallel, she set up a research team of Pharmacoepidemiology from 2003, team which joined the French National Institute of Research (INSERM) in 2011 in the UMR 1027 “ Epidémiologie et Analyses en Santé Publique”.

Her areas of research include evaluation of long term effects of drugs and drug safety. She has a particular interest in drug misuse and abuse and addiction to medications and performs research on determinants and outcomes of psychoactive drug use.


◦ 1998-present: Associate Professor of Clinical Pharmacology, Toulouse III University

◦ 1991-1998: Hospital practitionner, Toulouse Hospital


1997: HDR (Ph.D. supervision), Toulouse III University

1991: Ph.D. Public Health

1991: Medical Doctor

Research fields

Clinical research and clinical pharmacology, pharmacoepidemiology, addiction research, psychoactive drugs


More than 320 publications, (h index = 36).

Driot D, Jouanjus E, Oustric S, Dupouy J, Lapeyre-Mestre M. Patterns of gabapentin and pregabalin use and misuse: results of a population-based cohort study in France. Br J Clin Pharmacol. 2019 Feb 8. doi: 10.1111/bcp.13892.

de Germay S, Rueter M, Montastruc F, Rousseau V, Lapeyre-Mestre M, Montastruc JL. Trends of atropinic (anticholinergic) exposure in the elderly: a 10-year analysis in the French EGB database. Fundam Clin Pharmacol. 2019 Jan 27. doi:10.1111/fcp.12450.

Jouanjus E, Falcou A, Deheul S, Roussin A, Lapeyre-Mestre M. Detecting the diverted use of psychoactive drugs by adolescents and young adults: A pilot study. Pharmacoepidemiol Drug Saf. 2018 Nov;27(11):1286-1292. doi: 10.1002/pds.4624.

Revet A, Montastruc F, Raynaud JP, Baricault B, Montastruc JL, Lapeyre-Mestre M. Trends and Patterns of Antidepressant Use in French Children and Adolescents From 2009 to 2016: A Population-Based Study in the French Health InsuranceDatabase. J Clin Psychopharmacol. 2018 Aug;38(4):327-335. doi:10.1097/JCP.0000000000000891.

Ponté C, Lepelley M, Boucherie Q, Mallaret M, Lapeyre Mestre M, Pradel V, Micallef J. Doctor shopping of opioid analgesics relative to benzodiazepines: A pharmacoepidemiological study among 11.7 million inhabitants in the French countries. Drug Alcohol Depend. 2018 Jun 1;187:88-94. doi:10.1016/j.drugalcdep.2018.01.036.

Cool C, Cestac P, McCambridge C, Rouch L, de Souto Barreto P, Rolland Y, Lapeyre-Mestre M. Reducing potentially inappropriate drug prescribing in nursing  home residents: effectiveness of a geriatric intervention. Br J Clin Pharmacol. 2018 Jul;84(7):1598-1610. doi: 10.1111/bcp.13598.

Grants and Awards (selection)

Programme Hospitalier de Recherche Clinique (PHRC 2013 et 2016), INCA 2017, Appels à Projets ANSM (project leader or co-investigator) 2016 ; 2017

External services

Editorial board of the British Journal of Clinical Pharmacology

Scientific expert for the French PHRC, Fonds National de la Recherche Scientifique (Belgique), Swiss National Scientific Foundation, IMI (EU)

Participant to “Expertise Collective de l’Inserm”: Usage et Mésusage des médicaments psychotropes (2012) ; Dopage et conduites dopantes en milieu sportif (2019)